Plantar Spitz Nevus Resembling Malignant Melanoma: Description of Immunohistochemical Findings

Spitz nevus (SN) is predominantly distributed throughout the lower extremities, while an acral location rare. Since SN occasionally resembles clinicopathological presentation of malignant melanoma (MM), it presents a diagnostic challenge, especially on glabrous skin. Past reports suggest that several genetic aberrations are associated with specific subtypes melanocytic tumors. Immunohistochemistry can provide clue to presence or absence molecular aberration typical We describe case plantar analysis, including anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), BRAF (V600E) protein, and BRCA1-associated protein-1 (BAP1). However, we were not able detect characteristic gene aberration. To best our knowledge, no in cases have been reported. A comprehensive understanding tumor genomics expected play essential role classification Further research required establish new criteria for distinguishing between MM.